Case Clinic 1: Woman Previously Treated for HCV

PROGRAM DESCRIPTION In this Case Clinic, Bruce Bacon, MD, discusses the management of a 61-year-old woman with type 2 diabetes mellitus, hypertension, and an elevated body mass index who was ...

PROGRAM DESCRIPTION
In this Case Clinic, Bruce Bacon, MD, discusses the management of a 61-year-old woman with type 2 diabetes mellitus, hypertension, and an elevated body mass index who was unsuccessfully treated for hepatitis C virus (HCV) infection with an interferon-based regimen 15 years ago. Recent testing has revealed HCV genotype 1a and advanced fibrosis; she also is positive for NS5A resistance. The case discussion highlights how findings of resistance and advanced fibrosis affect management as well as the importance of post-treatment surveillance for hepatocellular carcinoma.

EDUCATIONAL OBJECTIVES
At the conclusion of this activity, participants should be better able to:Select the appropriate direct-acting antiviral (DAA) agent for hepatitis C virus (HCV) infection based on viral genotypes (and subtype) and associated complicationsImplement strategies, including the spectrum of molecular testing protocols, to identify and monitor disease progression and treatment efficacy and potentially avert HCV treatment resistanceFacilitate better linkage of care among specialists and other providers to strengthen screening, treatment, and monitoring practices, particularly for underserved and marginalized populations

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