Evolving Expectations in the Management of Relapsing-Remitting MS

PROGRAM DESCRIPTION Incomplete recovery from relapses in individuals with relapsing-remitting multiple sclerosis (RRMS) contributes to stepwise disability worsening, underscoring the importance of early, effective intervention. After many years in which ...

PROGRAM DESCRIPTION
Incomplete recovery from relapses in individuals with relapsing-remitting multiple sclerosis (RRMS) contributes to stepwise disability worsening, underscoring the importance of early, effective intervention. After many years in which first-line disease-modifying therapies (eg, glatiramer acetate, interferon-β) were the principal treatment options, a plethora of new agents for MS treatment—including next-generation sphingosine-1-phosphate (S1P) receptor modulators—are now approved or under investigation. These emerging options are raising the bar from the current therapeutic goals of achieving minimal evidence of disease activity to the potential, albeit ambitious, goal of achieving no evidence of disease activity—meaning no relapses, no disability worsening, and no new or enlarging lesions on magnetic resonance imaging.

EDUCATIONAL OBJECTIVES
At the conclusion of this activity, participants should be better able to:Analyze the disease course of relapsing-remitting multiple sclerosis (RRMS) and the impact of early diagnosisDescribe how the introduction of disease-modifying therapy—including oral sphingosine 1-phosphate (S1P) receptor modulators—has transformed expectations for reducing inflammatory lesion activity in patients with RRMSExplain the mechanisms of action of S1P receptor modulators and their rationale for treatment for patients with RRMSInterpret the efficacy and safety of current and emerging S1P receptor agents, including their benefit/risk profiles and effects on cardiac healthUtilize shared decision-making with patients when discussing a new treatment and/or a change in therapeutic regimenAddress nonmotor symptoms of MS such as depression and fatigue

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